CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension
نویسندگان
چکیده
Alistair C. Church, Damien H. Martin, Roger Wadsworth, Gareth Bryson, Andrew J. Fisher, David J. Welsh,* and Andrew J. Peacock* Scottish Pulmonary Vascular Unit, University of Glasgow, Glasgow, United Kingdom; Department of Cardiovascular Biology, University of Strathclyde, Glasgow, United Kingdom; Department of Pathology, Southern General Hospital, Glasgow, United Kingdom; and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
منابع مشابه
The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension
The p38 mitogen-activated protein kinase (MAPK) system is increasingly recognized as an important inflammatory pathway in systemic vascular disease but its role in pulmonary vascular disease is unclear. Previous in vitro studies suggest p38 MAPKα is critical in the proliferation of pulmonary artery fibroblasts, an important step in the pathogenesis of pulmonary vascular remodeling (PVremod). In...
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Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reportedto be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammat...
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Hypoxia-induced endothelial dysfunction plays a crucial role in the pathogenesis of hypoxic pulmonary hypertension. p38 MAPK expression is increased in the pulmonary artery following hypoxic exposure. Recent evidence suggests that increased p38 MAPK activity is associated with endothelial dysfunction. However, the role of p38 MAPK activation in pulmonary artery endothelial dysfunction is not kn...
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MicroRNAs (miRNAs) have emerged as a new class of posttranscriptional regulators ofmany cardiac and vascular diseases.They are a class of small, noncoding RNAs that contributes crucial roles typically through binding of the 3-untranslated region of mRNA. A singlemiRNAmay influence several signaling pathways associatedwith cardiac remodeling by targetingmultiple genes. Pulmonary hypertension (PH...
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